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Treatment options are limited to symptomatic therapy and (rarely) surgical intervention.
HCQ (originally an antimalarial drug) is a disease modifying drug (DMARD) used for inflammatory erosive OA in clinical practice.
The co-primary clinical endpoints are the changes in Australian-Canadian OA Index (AUSCAN, German version) dimensions for pain and hand disability at week 52.
The co-primary radiographic endpoint is the radiographic progression from baseline to week 52.
Osteoarthritis (OA) is a heterogeneous group of conditions with defective integrity of articular cartilage and changes in the underlying bone.
The pathogenesis is multifactorial and involves a complex interplay of genetic, metabolic, biochemical, and biomechanical factors with variable components of inflammation.